Spill and kill

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Spill and kill

L ysosomes spill their guts and kill their host cells, as revealed on page 231. Artal-Sanz et al. show that cells are more likely to escape a necrotic death sentence if they contain less acidic lysosomes. Necrosis—considered the unprogrammed counterpart to apoptotic death—is the deadly result of a severe and abrupt loss of energy, nutrients, or oxygen. These stimuli create sudden alterations in...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2006

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.1732iti1